Latest 'miracle' medicine for postpartum Depression one step closer to approval

07/03/2021

Pregnancy can bring many difficulties that directly affect the baby's health, mother's health, or both. Therefore, to be healthy for mothers, not only during pregnancy but also important after giving birth. For example, one of the conditions that women experience during and after pregnancy is to feel emptiness and loneliness, generally called Postpartum Depression. It happens because women's bodies experience many changes such as hormones, weight gain, muscle enlargement and stretching, and others. 

What Actually Postpartum Depression Is, and What Researchers Said?

Postpartum Depression refers to the baby blues that are quite common in new mothers full of emotional swings. Like to feel sad, exhausted, worried, or maybe hopeless. It can be considered normal for weeks, but some have severe depression that badly impacts on mother's and baby's health at the same time. 

Postpartum Depression has a stronger intensity and stays configured for a long time. Postpartum Depression is a severe illness that should not be overlooked. It's a terrible condition, but with therapy, it can be conquered.

It is reported that 9 out of 10 women experience postpartum depression after the child's birth. However, another research of NHI discovered the level of depression varies, and most mothers encounter it.

The National Institutes of Health collected data from 5,000 women in the Upstate KIDS research in New York. They discovered that roughly one in every four mothers had significant levels of Depression three years after giving birth. However, throughout the three years, the other women reported modest levels of depression.

The Miracle Drug Is One Step Away from Its Approval

Postpartum Depression is the most common complication found in females. Many researchers spent years finding out the cure for postpartum depression, and on Wednesday, they got something that is revealed now. 

Postpartum Depression, like other mental health disorders that only affect women, has long been understudied and under-researched. As a result, it often remains undetected despite the terrible consequences for both mother and child.

The new Postpartum depression drug Zuranolone was discovered by the scientist of "Northwell Health's Feinstein," They examined it completely and gave a clinical trial examining the novel medicine Zuranolone and discovered that more than half of the subjects had complete remission of their clinical depression after the study.

Women suffering from postpartum depression have a hard time bonding with their children or caring for them. They are frequently plagued with emotions of despair, stress, and terrible views about their perceived inability to be a mother. Studies show that in most severe cases, mothers attempt suicide and end their life.

The neuroactive steroid tablet also worked considerably faster than traditional antidepressants for women with depression, with study participants reporting "instantaneous and persistent outcomes" after just three days on the medication, according to Northwell Health.

In a double-blinded, placebo-controlled experiment, the Feinstein Institutes evaluated 151 randomized patients at 33 locations across the United States as part of the Postpartum depression drug's critical Phase 3 research. 

After day 15, 45% had acquired remission, compared to 23% in the placebo group, and by day 45, 53% had ensured complete remission, compared to 30 percent in the placebo group.

Kristina Deligiannidis, MD, of the Feinstein Institutes for Medical Research in Manhasset, New York, and colleagues told MedPage, "Women with postpartum depression who participated in this research reported a fast decrease in both depression and anxiety symptoms."

Deligiannidis and colleagues found that 13.2% of new moms suffer from postpartum depression. Postpartum Depression is one of the most frequent problems during and after pregnancy, yet it is often overlooked and untreated.

Deligiannidis further said that this is the "1st oral neuroactive steroid to be studied in women with postpartum depression" and that the medicine might be a quick-acting alternative for patients. Furthermore, patients may use selective serotonin or norepinephrine reuptake inhibitors (SSRIs or SNRIs) to treat prenatal or postpartum mood disorders, and brexanolone (Zulresso) is already accessible in therapeutic settings.

These positive results of examining new Postpartum depression drugs are good news for all the women out there who suffered from postpartum depression. 

Symptoms of Postpartum Depression-Take Notes

One real case shows that mothers feel uncomfortable and unhappy and feel so exhausted to provide child care. In this way, the baby's health faces issues and affects their upbringing. 

If you experience postpartum depression, you're probably aware of some of these symptoms. However, the major symptoms will be:

  • You're sleeping far too much.
  • The feeling of sorrow and sadness without any reason
  • You either can't stop eating or don't care about food at all.
  • You're tired, yet you can't fall asleep.
  • You're experiencing a variety of inexplicable aches, pains, or diseases.
  • You have a sense of being out of control.
  • Everything seems bleak and overpowering.
  • You feel useless and ashamed of your emotions.
  • You have mood swings that shift abruptly and unexpectedly.
  • You are unable to focus or make straightforward judgments.
  • You've uninterested in activities that you used to like.
  • You don't pay attention to your kid and are puzzled about why you aren't as happy as you expected.
  • You're not sure what's making you irritated, nervous, or furious.
  • You have trouble recalling information.
  • You're having uncontrollable feelings about hurting yourself or your child.
  • Dizziness, befuddlement, and babbling
  • a weird or unpredictable pattern of conduct
  • anger or aggressive behavior
  • Suicidal ideation or suicide attempt
  • You're having second thoughts about hurting your child.
  • Hallucinations occur when you see, hear, smell, or feel things that aren't there.
  • Having delusions or illogical ideas, attaching too much significance to minor things, or feeling targeted are all examples of delusions.

These are the main symptoms diagnosed at the initial stages and get worse until you end your life. Your family can see these unconscious changes in your behavior and may notice that you've become distant from them and or that you don't appear like yourself.

How to Deal with Postpartum Depression

Postpartum Depression might worsen over time if it is not treated. It's the most harmful when it makes you want to hurt yourself or others. When these thoughts start to arise, therapeutic help is required. 

Join Social Gatherings

If you're a naturally reticent person, you might be inclined to keep your sentiments to yourself. When you feel PPD, staying connected with your friends and families, enjoying social gatherings, sharing your thoughts with others, and enjoyable evenings can help you reduce the level of depression. However, talking things out with someone you trust can be beneficial. You may discover that you're not alone, and others are prepared to listen.

Keep Yourself Engage

The more you spend alone time, the more you feel exhausted and frustrated. So instead, try to engage yourself in the activities that may help you to fight PPD. Yoga, exercise, and gyming are the best ways to keep yourself in productive activities that may help you fight isolation. 

Medications 

In this scenario, doctors are your best friend. Keep in touch with your consultants to develop an effective routine. Take medications and eat nutritious foods to keep your body in good shape while also refreshing it. When you consume a healthy diet, your medicine works swiftly and effectively to help you overcome depression.

Take Rest and Relax

A good night's sleep is necessary for both your physical and spiritual well-being. If your kid doesn't sleep for lengthy periods, hire someone to babysit for you so you can get some rest. If you're having problems falling asleep, try a hot bath, a nice book, or anything else that relaxes you. Meditation and therapy can both help you relax and stay asleep.

If you feel more at ease in a group environment, consider joining groups or a group of newly blessed parents. If you've given up on formerly fun group activities, give them another shot to see if it aids. Being in a group might assist you in focusing on other things while also reducing stress.

Bottom Line

Although symptoms might begin throughout pregnancy, PPD is a manic depressive disorder that happens after delivery. It is marked by sorrow and lack of interest in previously enjoyed activities, as well as a diminished capacity to feel pleasure (anhedonia). In addition, it may include symptoms such as memory loss, feelings of failure or sorrow, or suicidal ideation.

In phase III clinical research, Zuranolone was both safe and effective in decreasing symptoms of postpartum depression. Therefore, as soon as the newly produced Postpartum depression drug comes on the market, women can take it at the recommendation of their doctors or consultants. Postpartum depression drugs will surely help come across the challenges faced by the newly blessed mothers and enjoy their quality time with their newly born babies. 

Zuranolone will be tested in other experiments at varying dosages and over longer periods. However, many women continue to suffer from postpartum depression symptoms without seeking therapy. The mothers can make available medications and practice the tips mentioned above to overcome postpartum depression.