Predict Your Immune System By Using “AI Aging Clock” (iAge)

07/18/2021

From 2020 till onward, we frequently hear you could survive from the coronavirus if your immune system is robust. People who have balanced immune power recover more quickly from it. Besides this, what indicates that your immune system is strong or not?

Do you know, age is the main reason that gauges your immune power. And for this, technology again hits the ground running. It means by the help of AI now; you can:

  • Evaluate your body's immune system
  • Have complete knowledge about how feeble you'll be shortly, and
  • How much strength is in your body to accept changes.

We discuss it later, but first, you have to know what the immune system is and why it is essential.

Let's define the immune system!

For human survival, the immune system is an imperative component. Our body would be vulnerable to germs, bacteria, parasites, and other pathogens if we didn't have an immune system. In addition, as our surroundings are full of germs and diseases, it is our immune system that keeps us healthy.

Various tissues, organs, enzymes, and cells are the immune system components circulating throughout the body. It can also differentiate the human and alien tissue. The immune system also identifies and eliminates damaged and defective cells.

The immune system produces an immunological reaction when it comes into contacts with a disease, such as a germ like bacteria, virus, or parasite. 

We'll talk about how this works later, but first, let's become acquainted with one of the immune system's major players.

White Blood Cells

White blood cells travel through the body in blood vessels and lymphatic channels parallel to the veins and arteries. Another name for white blood cells is leukocytes. 

White blood cells are sensitive and always on the lookout for infections. They find the chance to get affected and increase when they recognize the victim. Also, they gather other forms of cells by sending signals to participate in strengthening the human body.

Lymphoid organs contain white blood cells, which are available throughout the body. The following are some of them:

  • Bone marrow is found in the core of the bones. It produces white blood cells.
  • Lymph nodes are tiny glands that are found all over the body and are associated with lymphatic veins.
  • The spleen is a filtration organ for the blood. It's behind your left ribs and on the top left side of your abdomen.
  • The gland located between the lungs and slightly below the collarbone refers to a thymus.

Everyone's immune system is unique, but it tends to get more significant and more potent. As we get older, we've been exposed to more infections and built more immunity. As a result, teenagers and adults get ill less frequently than children.

When antibodies appear in our body, it saves and stores the version. So if the same bacteria get attacked next time, your body will be capable of handling it more swiftly.

By the reservation of antibodies, many diseases will not affect you, such as chickenpox. However, since antibodies took place in your system, it helps eliminate it the next time it appears. This process is the immunity in your system.

The researcher discovers AI-Based Aging Clock

Artificial Intelligence is an ultra-modern machine and a game to play in the technical industry. No doubt, it is a game-changer. In nearly every sector and nation, the current hype cycle in artificial intelligence (AI) resulted in massive development in machine learning and a rise in available expertise.

The new sensation in Meditech is Artificial Intelligence (AI). An AI-based aging clock (iAge) was built by the scientists at Stanford University School of Medicine and the Buck Institute.

The inflammatory aging clock (iAge) is among the first instruments to measure health using inflammation, published in the journal Nature Aging on July 12th.

It helps you detect the accurate measure of your immune power and predict how powerful and weak your immune system is. Not only this, but it also makes you aware of the unseen cardiovascular problem that can overtake you in the future.

David Furman, Ph.D., associate professor at the Buck Institute and head of the Artificial Intelligence Platform, said, "Standard immunological measures to identify persons most at risk for developing single or many chronic illnesses of aging have been critically lacking."

The leading players in this research are Nazish Sayed and Yingxiang Huang from Stanford University's School of Medicine in California. They worked on about 1000 Immunomes Projects.

In their research, they observed that cardiac aging has one more reason that is a chemokine. These scientists claim that it helps to reduce aging pathology and could also indicate a potentially flexible approach for therapies.

Do you know?

Chemokines refer to the small proteins scattered in the body through cells that affect the immune system. It plays an essential role in cell migration through very tiny blood vessels in the microcirculation from the blood into tissues and vice versa. 

A thorough examination of numerous immune system markers in the blood and figuring out the patterns and metrics associated with this chronic inflammatory response is based on the iAge algorithm. 

As a result of an examination, the iAge score helps you know the immunological health and inflammatory conditions dependent on individual age. The higher the iAge score implies a higher risk of illness, whereas a lower score implies a robust immunity.

By utilizing the records of the 1000 Immunomes Project from Stanford, they reached a positive conclusion. To create a benchmark for iAge, they accumulated blood samples from a 9-year longitudinal group of 1,001 patients under age from 8 to 96 years old.

The researchers could provide detailed insight into the immune system and find possible indicators by evaluating these blood samples.

By 1,001 blood samples of the participants categorized by body mass index, age, sex, and other biological variables, they examine the more profound analysis of the immune system. 

What do they find?

By keeping a nonlinear comparison method in mind, the different metrics of inflammation linked with iAge score by levels of active immune-system molecules.

Immunosenescence

As a result of aging, Immunosenescence is the dysfunction and decline of the immune system. Chemokine (CXCL9) is a small protein particle circulates in the human body and connects to Immunosenescence. CXCL9 is a protein that controls immunology and inflammatory responses. This protein exhibited a positive connection with age at the start, and its levels dramatically elevated by the age of 60. Surprisingly, CXCL9 was the most critical contributor to the iAge pattern.

The underlying mechanism of CXCL9 in Immunosenescence might be that it affects endothelial cell function. The typical role of these cells found inside of blood arteries is to control blood circulation. On the other hand, injured endothelial cells can trigger inflammatory responses.

By investigating the role of CXCL9 in mice, the result is that the older mice had more CXCL9 in their endothelial cells, indicating that this protein damages endothelial cells. Atherosclerosis developed as a result of the injured cells. Other investigations have discovered that these injured endothelial cells cause cardiac muscle stiffening, which is a prelude to cardiovascular disease.

The analysis revealed that when CXCL9 synthesis rises with age, endothelial cells get disrupted, leading to a rise in inflammatory signals that lead to heart deterioration.

Longevity

The scientists composed a set of individuals aged 100 or older. Only 31% of the 19 people in the study had a high iAge score, while 68% had a weak iAge score.

In contrast, only 23% of participants in a comparison group of older ones had a low iAge score. Moreover, individuals above the age of 100 had reduced iAge at a much lower rate, implying that " Building iAge with extraordinary lifespan."

Multimorbidity

There was an essential link between multimorbidity and iAge. Multimorbidity is the several chronic inflammatory pathologies. As soon as the body hits the 60s, an increase in iAge was associated with an upsurge in multimorbidity.

It is reported that the overall sum of T lymphocytes and B lymphocytes, white blood cells, is an essential player in immunologic reaction and proved a comparable correlation.

Conclusion

To sum up, the new AI technique allows for the early detection of inflammatory pathologies and immune system deterioration. Thus, it can assist and identify people who are at risk of acquiring a disease possibly a bit earlier on and move to preventative steps that will improve their well-being.

A thoughtful conclusion by the author mentioned in the research:

"We develop an inflammatory clock of aging by using artificial intelligence algorithms to deep immunological monitoring of human blood, which may be utilized as a companion diagnostic to educate clinicians about a patient's inflammatory load and overall health state, especially those with chronic diseases."

The development of iAge adds to a growing number of aging clocks that anticipate health concerns and refers to the biological processes by providing crucial immune-related information. AI does its best to make the health industry more advanced to be aware of their health. However, it is better to prevent than cure. By using the iAge clock, you will know about the immune system score. So, early treatment is far better than late.